Study of Thrombophilia in Recurrent Pregnancy Loss

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Thrombophilia and Recurrent Pregnancy Loss

Recurrent pregnancy loss (RPL) is usually defined as the loss of three or more consecutive pregnancies before 20 weeks of gestation. Within this definition is a large and heterogeneous group of patients with many different causes of miscarriage. RPL is a common clinical problem that occurs in approximately 1 % of reproductive-aged women. However, this frequency increases up to 5% when clinician...

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Recurrent Pregnancy Loss and Thrombophilia

In the last decades we found many data concerning the association between a hypercoagulable state and its causes and adverse pregnancy outcome, in particular recurrent pregnancy loss (RPL). Although first studies were focused only on the association between thrombophilia and RPL, subsequent studies underlined also a potential role of antithrombotic treatment to prevent vascular complication suc...

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Thrombophilia abnormalities in recurrent pregnancy loss

Recent evidences associate thrombophilia with adverse pregnancy outcome. Numerous studies confirm Factor V Leiden (FVL) and Prothrombin G20210A (PT G20210A) mutations as important thrombophilia risk factors in Caucasians. However, these mutations are rare in Asians and thrombophilia investigations are therefore considered irrelevant in these patients. Hence, the status of thrombophilia-induced ...

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Inherited Thrombophilia and Recurrent Pregnancy Loss

BACKGROUND Recurrent pregnancy loss (RPL) is a common health problem. The polymorphisms G20210A of prothrombin gene (FII G 20210A), and G 1691A of factor V gene (Factor V Leiden, FVL) are the most extensively studied thrombophilic mutations in association to recurrent miscarriage. OBJECTIVES To determine the frequency of FII G20210A and FVL polymorphisms as well as protein C and protein S def...

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inherited thrombophilia and recurrent pregnancy loss

conclusions: we determined a significant higher frequency of protein s deficiency in patients with rpl compared with controls. but the frequency of protein c deficiency and the frequency of two common thrombophilic mutations (factor v leiden and prothrombin g20210a), were not significantly different between patients with recurrent miscarriage and healthy women. results: the mean functional acti...

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ژورنال

عنوان ژورنال: The Journal of Obstetrics and Gynecology of India

سال: 2012

ISSN: 0971-9202,0975-6434

DOI: 10.1007/s13224-012-0197-x